Degradation of multiplier phototubes exposed to spatial radiations

Degradation of multiplier phototubes exposed to spatial radiation

Taste symmetry breaking with HYP-smeared staggered fermions

We study the impact of hypercubic (HYP) smearing on the size of taste breaking for staggered fermions, comparing to unimproved and to asqtad-improved staggered fermions. As in previous studies, we find a substantial reduction in taste-breaking compared to unimproved staggered fermions (by a factor of 4-7 on lattices with spacing $a\approx 0.1$fm). In addition, we observe that discretization effects of next-to-leading order in the chiral expansion (${\cal O}(a^2 p^2)$) are markedly reduced by HYP smearing. Compared to asqtad valence fermions, we find that taste-breaking in the pion spectrum is reduced by a factor of 2.5-3, down to a level comparable to the expected size of generic ${\cal O}(a^2)$ effects. Our results suggest that, once one reaches a lattice spacing of $a\approx 0.09$fm, taste-breaking will be small enough after HYP smearing that one can use a modified power counting in which ${\cal O}(a^2) \ll {\cal O}(p^2)$, simplify fitting to phenomenologically interesting quantities.Comment: 14 pages, 13 figures, references updated, minor change

Dilaton Stabilization and Inflation in the D-brane World

We study the dilaton stabilization in the D-brane world in which a D-brane constitutes our universe. The dilaton can be stabilized due to the interplay between the D-brane tension and the negative scalar curvature of extra dimensions. Cosmic evolution of the dilaton is investigated with the obtained dilaton potential and it is found that inflation can be realized before the settlement of the dilaton.Comment: 10 pages, abstract correcte

Cauchy problem for the Boltzmann-BGK model near a global Maxwellian

In this paper, we are interested in the Cauchy problem for the Boltzmann-BGK model for a general class of collision frequencies. We prove that the Boltzmann-BGK model linearized around a global Maxwellian admits a unique global smooth solution if the initial perturbation is sufficiently small in a high order energy norm. We also establish an asymptotic decay estimate and uniform $L^2$-stability for nonlinear perturbations.Comment: 26 page

Neutron and muon-induced background studies for the AMoRE double-beta decay experiment

AMoRE (Advanced Mo-based Rare process Experiment) is an experiment to search a neutrinoless double-beta decay of $^{100}$Mo in molybdate crystals. The neutron and muon-induced backgrounds are crucial to obtain the zero-background level (<$10^{-5}$ counts/(keV$\cdot$kg$\cdot$yr)) for the AMoRE-II experiment, which is the second phase of the AMoRE project, planned to run at YEMI underground laboratory. To evaluate the effects of neutron and muon-induced backgrounds, we performed Geant4 Monte Carlo simulations and studied a shielding strategy for the AMORE-II experiment. Neutron-induced backgrounds were also included in the study. In this paper, we estimated the background level in the presence of possible shielding structures, which meet the background requirement for the AMoRE-II experiment

A V-Diagram for the Design of Integrated Health Management for Unmanned Aerial Systems

Designing Integrated Vehicle Health Management (IVHM) for Unmanned Aerial Systems (UAS) is inherently complex. UAS are a system of systems (SoS) and IVHM is a product-service, thus the designer has to take into account many factors, such as: the design of the other systems of the UAS (e.g. engines, structure, communications), the split of functions between elements of the UAS, the intended operation/mission of the UAS, the cost verses benefit of monitoring a system/component/part, different techniques for monitoring the health of the UAS, optimizing the health of the fleet and not just the individual UAS, amongst others. The design of IVHM cannot sit alongside, or after, the design of UAS, but itself be integrated into the overall design to maximize IVHM’s potential. Many different methods exist to help design complex products and manage the process. One method used is the V-diagram which is based on three concepts: decomposition & definition; integration & testing; and verification & validation. This paper adapts the V-diagram so that it can be used for designing IVHM for UAS. The adapted v-diagram splits into different tracks for the different system elements of the UAS and responses to health states (decomposition and definition). These tracks are then combined into an overall IVHM provision for the UAS (integration and testing), which can be verified and validated. The stages of the adapted V-diagram can easily be aligned with the stages of the V-diagram being used to design the UAS bringing the design of the IVHM in step with the overall design process. The adapted V-diagram also allows the design IVHM for a UAS to be broken down in to smaller tasks which can be assigned to people/teams with the relevant competencies. The adapted V-diagram could also be used to design IVHM for other SoS and other vehicles or products

Measurement and models accounting for cell death capture hidden variation in compound response.

Cancer cell sensitivity or resistance is almost universally quantified through a direct or surrogate measure of cell number. However, compound responses can occur through many distinct phenotypic outcomes, including changes in cell growth, apoptosis, and non-apoptotic cell death. These outcomes have divergent effects on the tumor microenvironment, immune response, and resistance mechanisms. Here, we show that quantifying cell viability alone is insufficient to distinguish between these compound responses. Using an alternative assay and drug-response analysis amenable to high-throughput measurement, we find that compounds with identical viability outcomes can have very different effects on cell growth and death. Moreover, additive compound pairs with distinct growth/death effects can appear synergistic when only assessed by viability. Overall, these results demonstrate an approach to incorporating measurements of cell death when characterizing a pharmacologic response

Release of proteins via ion exchange from albumin-heparin microspheres

Albumin-heparin and albumin microspheres were prepared as ion exchange gels for the controlled release of positively charged polypeptides and proteins. The adsorption isotherms of chicken egg and human lysozyme, as model proteins, on microspheres were obtained. An adsorption isotherm of chicken egg lysozyme on albumin-heparin microspheres was linear until saturation was abruptly reached,\ud \ud The adsorption isotherms of human lysozyme at low and high ionic strength were typical of adsorption isotherms of proteins on ion exchange gels. The adsorption of human lysozyme on albumin-heparin and albumin microspheres fit the Freundlich equation suggesting heterogeneous binding sites. This was consistent with the proposed multivalent, electrostatic interactions between human lysozyme and negatively charged microspheres. Scatchard plots of the adsorption processes of human lysozyme on albumin-heparin and albumin microspheres suggested negative cooperativity, while positive cooperativity was observed for chicken egg lysozyme adsorption on albumin-heparin microspheres.\ud \ud Human lysozyme loading of albumin-heparin microspheres was 3 times higher than with albumin microspheres, with long term release occurring via an ion exchange mechanism. Apparent diffusion coefficients of 2.1 × 10-1 and 3.9 × 10-11cm2/sec were obtained for the release of human lysozyme from albumin-heparin and albumin microspheres, respectively. The release was found to be independent of diffusion, since the rate determining step was likely an adsorption/desorption processes. An apparent diffusion coefficient of 4.1 × 10-12 cm2/sec was determined for the release of chicken egg lysozyme from albumin-heparin microspheres.\ud \ud Low release of the lysozymes from albumin-heparin microspheres was observed in deionized water, consistent with the proposed ion exchange release mechanism. Overall, albumin-heparin microspheres demonstrated enhanced ion exchange characteristics over albumin microspheres